Aichi Virus Positivity in HIV-1 Seropositive Children Hospitalized with Diarrheal Disease

Title:Aichi Virus Positivity in HIV-1 Seropositive Children Hospitalized with Diarrheal Disease

Volume: 13 Issue: 4

Author(s): Silvana Augusta Rodrigues Portes, Eduardo de Mello Volotao, Tatiana Lundgren Rose, Monica Simoes Roch, Maria da Penha Trindade Pinheiro Xavier, Rosane Maria de Assis, Alexandre Madi Fialho, Myrna Santos Rocha, Marize Pereira Miagostovich, Jose Paulo Gagliardi Leite and Filipe Anibal Carvalho-Co

Affiliation:

Keywords: Aichi virus, AIDS, children, diarrheal disease, HIV-1, oportunistic agent.

Abstract: Aichi viruses (AiV) have been detected in patients with diarrheal diseases (DD). The aim of this study was to assess AiV infection rates in hospitalized children with DD, including 123 HIV-1 seropositive and 125 HIV-1 seronegative patients, in two public pediatric hospitals in Rio de Janeiro, Brazil. AiV was investigated by nested RT-PCR. The AiV-positive samples were also tested for specie A rotavirus, norovirus, astrovirus, enteric adenovirus and bocavirus in order to assess co-infections. AiV parcial genome sequencing and phylogenetic analyses were performed. AiV were detected in 9/123 (7.32%) of the HIV-1 seropositive subjects and 1/125 (0.8%) of the HIV seronegative patients with DD (p = 0.019). The phylogenetic analysis of positive samples disclosed that: i) 13 samples were characterized as genotype A, with one of them being from the HIV-1 seronegative patient; ii) one sample from a HIV-1 seropositive patient was characterized as genotype B. AiV genotype A was grouped into 3 genetic clusters. Data suggest that AiV may be an opportunistic pathogen infecting children with AIDS and DD.

Cite this article as:

Rodrigues Portes Augusta Silvana, de Mello Volotao Eduardo, Rose Lundgren Tatiana, Roch Simoes Monica, Trindade Pinheiro Xavier da Penha Maria, de Assis Maria Rosane, Fialho Madi Alexandre, Rocha Santos Myrna, Miagostovich Pereira Marize, Gagliardi Leite Paulo Jose and Carvalho-Co Anibal Filipe, Aichi Virus Positivity in HIV-1 Seropositive Children Hospitalized with Diarrheal Disease, Current HIV Research 2015; 13 (4) . https://dx.doi.org/10.2174/1570162X13666150511145950