Voltage gated calcium channels (Cav) are composed of up to five proteins: The ion conducting
pore subunit α1 and the auxiliary subunits α2, δ, β, and γ. Recent reports show that Cavα1 and
Cavβ comprise the calcium channel core complex and that β, α2 δ and γ may serve additional roles that
are independent of the Cavα1 subunit. This short review will summarize these emerging functions.
Keywords: Auxiliary subunits, heart, insulin secretion, neurons, non-smooth muscle cells, pain perception
voltage-gated calcium channel.
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