Voltage-gated calcium channels are not only mediators of cell signalling events, but also
are recipients of signalling inputs from G protein coupled receptors (GPCRs) and their associated
second messenger pathways. The coupling of GPCRs to calcium channels is optimized through the
formation of receptor-channel complexes. In addition, this provides a mechanism for receptorchannel
co-trafficking to and from the plasma membrane. On the other hand, voltage-gated calcium
channel activity affects other types of ion channels such as voltage-and calcium-activated potassium
channels. Coupling efficiency between these two families of channels is also enhanced
through the formation of channel-channel complexes. This review provides a concise overview of the current state of
knowledge on the physical interactions between voltage-gated calcium channels and members of the GPCR family,
and with other types of ion channels.
Keywords: Calcium channels, G proteins, receptors, potassium channels, calcium-activated potassium channels, cell signaling.
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