Recent Applications of Phosphane-based Palladium Catalysts in Suzuki-Miyaura Reactions Involved in Total Syntheses of Natural Products

Author(s): Renzo Rossi , Fabio Bellina , Marco Lessi , Chiara Manzini , Giulia Marianetti , Luca A. Perego .

Journal Name: Current Organic Chemistry

Volume 19 , Issue 14 , 2015

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Abstract:

This review with 800 references illustrates applications of Suzuki-Miyaura (S.-M.) reactions in the total syntheses of 147 natural products that were made in the period 2010–2013. The review has been organized on the basis of the seven classes of phosphane-based Pd catalysts that have been used in the reported total syntheses. Emphasis has been given to describe and discuss the experimental conditions of the Pd-catalyzed (S.-M.) cross-coupling reactions also outlining the methods used to prepare the reactants. A focus has also been set on the biological and pharmacological properties of the reported natural products as well as on the most significant steps of the reported total syntheses.

Keywords: Carbon–carbon bond forming reactions, chemoselectivity, siteselectivity, stereoselectivity, transition metal catalyst.

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Article Details

VOLUME: 19
ISSUE: 14
Year: 2015
Page: [1302 - 1409]
Pages: 108
DOI: 10.2174/1385272819666150506230050
Price: $58

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