Fullerene and its derivatives are currently one of the most intensively investigated species
in the area of nanomedicine and nanochemistry. Various unique properties of fullerenes are responsible
for their wide range applications in industry, biology and medicine. A large pool of functionalized
C60 and C70 fullerenes is investigated theoretically at different levels of quantum-mechanical theory.
The semiempirial PM6 method, density functional theory with the B3LYP functional, and correlated ab initio MP2
method are employed to compute the optimized structures, and an array of properties for the considered species. In addition
to the calculations for isolated molecules, the results of solution calculations are also reported at the DFT level, using
the polarizable continuum model (PCM). Ionization potentials (IPs) and electron affinities (EAs) are computed by means
of Koopmans’ theorem as well as with the more accurate but computationally expensive ΔSCF method. Both procedures
yield comparable values, while comparison of IPs and EAs computed with different quantum-mechanical methods shows
surprisingly large differences. Harmonic vibrational frequencies are computed at the PM6 and B3LYP levels of theory
and compared with each other. A possible application of the frequencies as 3D descriptors in the EVA (EigenVAlues)
method is shown. All the computed data are made available, and may be used to replace experimental data in routine applications
where large amounts of data are required, e.g. in structure-activity relationship studies of the toxicity of
Keywords: Fullerene, PM6, B3LYP, MP2, Eigenvalue, PCM, Ionization potential, Electron affinity.
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