Bone Metastasis: Molecular Mechanisms Implicated in Tumour Cell Dormancy in Breast and Prostate Cancer
Penelope D. Ottewell,
Metastasis to the bone is most frequently observed in advanced cases of breast and prostate cancer. The latent
development of overt metastatic lesions is associated with debilitating skeletal morbidity and eventual patient mortality.
Secondary tumours in bone are derived from disseminated tumour cells (DTCs) that enter into a state of cellular
dormancy. The dormant state confers resistance to conventional chemotherapeutic agents and prevents elimination of
DTCs from the bone using current drug therapies. Expansion of our presently limited understanding of the molecular
mechanisms underpinning disseminated breast and prostate tumour cell dormancy is critical to the future development of
novel drug therapies aimed at the removal of DTCs, and thereby, the prevention of bone metastasis. This review provides
an overview of the main putative molecular mechanisms underlying cellular dormancy in breast and prostate cancer bone
metastasis reported from multiple experimental in vitro and in vivo models.
Keywords: Bone metastasis, breast, cancer, disseminated tumour cells, dormancy, prostate, quiescence.
Rights & PermissionsPrintExport