Five enantioselective sensors based on α-, β-, carboxymethyl-β-(as sodium salt),
2-hydroxyl-3-trimethylammoniopropyl -β-(as chloride salt) and γ-cyclodextrins were designed
based on results of their molecular interaction with the S- and R-enantiomers of ketoprofen
obtained using SPR (surface plasmon resonance) based sensors. SPR proved to be an excellent technique for selecting the
best chiral selectors. The best sensor was the one based on β-cyclodextrin. Low detection limits (of 10-8 to 10-9 magnitude
orders) were recorded with the enantioselective, potentiometric membrane electrodes.
Keywords: Cyclodextrin, enantioanalysis, enantioselective, potentiometric membrane electrode, S-ketoprofen, surface plasmon
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