Design of Potentiometric Sensors Based on Interaction of Cyclodextrins with the Enantiomer of Interest

Author(s): Raluca-Ioana Stefan-van Staden, Rahel Girmai Bokretsion, Jacobus Frederick van Staden, Hassan Y Aboul-Enein.

Journal Name: Current Drug Therapy

Volume 9 , Issue 4 , 2014

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Graphical Abstract:


Five enantioselective sensors based on α-, β-, carboxymethyl-β-(as sodium salt), 2-hydroxyl-3-trimethylammoniopropyl -β-(as chloride salt) and γ-cyclodextrins were designed based on results of their molecular interaction with the S- and R-enantiomers of ketoprofen obtained using SPR (surface plasmon resonance) based sensors. SPR proved to be an excellent technique for selecting the best chiral selectors. The best sensor was the one based on β-cyclodextrin. Low detection limits (of 10-8 to 10-9 magnitude orders) were recorded with the enantioselective, potentiometric membrane electrodes.

Keywords: Cyclodextrin, enantioanalysis, enantioselective, potentiometric membrane electrode, S-ketoprofen, surface plasmon resonance.

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Article Details

Year: 2014
Page: [250 - 255]
Pages: 6
DOI: 10.2174/1574885510999150505171712
Price: $58

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