The pineal hormone melatonin controls several physiological
functions that reach far beyond the regulation of the circadian rhythm.
Moreover, it can be produced in extra-pineal organs such as reproductive
organs. The role of melatonin in the mammalian seasonal and circadian
rhythm is well known. Nevertheless, its overall effect in male reproductive
physiology remains largely unknown. Melatonin is a very powerful endogenous
antioxidant that can also be exogenously taken safely. Interestingly, its
antioxidant properties have been consistently reported to improve the male reproductive dysfunctions
associated with pathological conditions and also with the exposure to toxicants. Nevertheless, the exact
molecular mechanisms by which melatonin exerts its action in the male reproductive system remain a matter of
debate. Herein, we propose to present an up-to-date overview of the melatonin effects in the male reproductive
health and debate future directions to disclose possible sites of melatonin action in male reproductive system.
We will discuss not only the role of melatonin during darkness and sleep but also the importance of the
antioxidant properties of this hormone to male fertility. Since melatonin readily crosses the physiological
barriers, such as the blood-testis barrier, and has a very low toxicity, it appears as an excellent candidate in the
prevention and/or treatment of the multiple male reproductive dysfunctions associated with various
Keywords: Antioxidant activity, melatonin, male reproductive system, sperm.
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