Title:Quercetin Potently Reduces Biofilm Formation of the Strain Pseudomonas aeruginosa PAO1 in vitro
VOLUME: 16 ISSUE: 8
Author(s):Boris Pejin, Ana Ciric, Jasmina D. Markovic, Jasmina Glamoclija, Milos Nikolic, Bojana Stanimirovic and Marina Sokovic
Affiliation:University of Belgrade, Institute for Multidisciplinary Research - IMSI, Department of Life Sciences, Belgrade, Serbia.
Keywords:Anti-biofilm activity, Anti-quorum sensing effects, Flavonoids, Pseudomonas aeruginosa PAO1.
Abstract:This work was focused on in vitro evaluation of anti-biofilm and anti-quorum sensing effects of four selected
flavonoid compounds /(+)-catechin, caffeic acid, quercetin and morin/ using the strain Pseudomonas aeruginosa PAO1.
At a concentration of 0.5 MIC quercetin was the only compound found to potently reduce both P. aeruginosa biofilm
formation (95%) and its twitching motility. The chemical scaffold of quercetin, a common dietary polyphenol, may actually
inspire development of novel and more effective medicinal agents targeting P. aeruginosa, the bacterium well known
for its resistance.
