Cancer Stem Cells, Models, Drugs and Future Prospective
Pp. 135-156 (22)
Ali Zekri, Mehrdad Asghari Estiar and Parvin Mehdipour
There is increasing evidence that malignant tumor is driven by tumorinitiating
cells or cancer stem cells (CSCs) have recently attracted a great number of
considerations for novel cancer therapy. The concept of cancer stem cell (CSCs) is an
appealing model to describe the functional heterogeneity of tumor cells. It suggests a
hierarchical organization of CSCs subpopulation to sustain tumor growth and
metastasis. CSCs could be resistant to standard anti-cancer drugs, which might describe
the limitations of these therapies. So, much work is required to identify and use of CSCs
as a target for anti-cancer treatment. This chapter focuses on the recent advances in the
cancer stem cell field and anticancer drug discovery.
Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.