A series of new asymmetric curcumin analogues were synthesized and
evaluated as potential multifunctional agents for the treatment of Alzheimer’s disease.
Our results showed that most of these synthetic compounds had better inhibitory properties
against Aβ aggregation compared with curcumin, and better anti-oxidative properties
compared with the reference compound Trolox through the study of oxygen
radical absorbance capacity (ORAC). Some compounds showed good properties in
selectively chelating metal ions such as copper and iron. Besides, some compounds
were found to be able to dissociate Aβ protein which had already aggregated. The structure-activity relationships (SAR)
of these synthetic compounds were studied. The present investigation indicated that our synthetic asymmetric curcumin
derivatives could be potential multifunctional agents for the treatment of Alzheimer’s disease (AD).
Keywords: Amyloid-beta aggregation, anti-Alzheimer’s agent, curcumin analogues, metal chelation, multifunctional inhibitor.
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