A Novel Tetradentate Ruthenium(II) Complex Containing Tris(2- pyridylmethyl)amine (tpa) as an Inhibitor of Beta-Amyloid Fibrillation

Author(s): Sharon Lai-Fung Chan , Lihua Lu , Tsz Lung Lam , Siu-Cheong Yan , Chung-Hang Leung , Dik-Lung Ma .

Journal Name: Current Alzheimer Research

Volume 12 , Issue 5 , 2015

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Abstract:

We report herein the synthesis and application of a novel tetradentate ruthenium(II) complex 1 containing a tris(2-pyridylmethyl)amine (tpa) ligand as an inhibitor of β-amyloid fibrillogenesis. [Ru(tpa)(bt)]ClO4 1 (bt =2-acetylbenzo[b]thiophene-3-olate) showed significant inhibition of Aβ(1-40) peptide aggregation in vitro, which was confirmed by a Thioflavin T assay and transmission electron microscopy imaging.

Keywords: 2-acetylbenzo[b]thiophen-3-olate, Alzheimer's disease, beta-amyloid, ruthenium(II), tris(2-pyridylmethyl)amine.

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Article Details

VOLUME: 12
ISSUE: 5
Year: 2015
Page: [434 - 438]
Pages: 5
DOI: 10.2174/1567205012666150504150726
Price: $58

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