Dual Inhibition and Monitoring of Beta-Amyloid Fibrillation by a Luminescent Iridium(III) Complex

Author(s): Chun-Yuen Wong, Lai-Hon Chung, Lihua Lu, Modi Wang, Bingyong He, Li-Juan Liu, Chung-Hang Leung, Dik-Lung Ma.

Journal Name: Current Alzheimer Research

Volume 12 , Issue 5 , 2015

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Abstract:

In this study, we report the synthesis and application of the novel cyclometallated luminescent Ir(III) complex 1 bearing the C^C^C ligand as a probe and inhibitor of Aβ fibrillation. We envisage that this kinetically-inert Ir(III) complex may be potentially developed as a dual-purpose probe and inhibitor of Aβ aggregation for Alzheimer’s disease diagnosis and treatment.

Keywords: Amyloid, aggregation, Alzheimer's, luminescent probe, iridium.

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Article Details

VOLUME: 12
ISSUE: 5
Year: 2015
Page: [439 - 444]
Pages: 6
DOI: 10.2174/1567205012666150504144558
Price: $58

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