A series of 26 quaternary ammonium pyridoxine derivatives were synthesized and their cytotoxicity
and antibacterial activities against clinically relevant bacterial strains were tested in vitro.
The antibacterial activity of mono-ammonium salts increased with the rise of the lipophilicity and
ium chloride (2d) reaches a maximum among them. Bis-ammonium salt of pyridoxine 4 with two dimethyloctylamine
groups also demonstrated high antibacterial activity despite lower lipophilicity. The
results of MTT assay indicated that HEK 293 cells were more sensitive than HSF to quaternary ammonium
pyridoxine derivatives. Compounds 2d and 4 did not induce the damage of the DNA and might be of interest in
the development of new antimicrobials.
Keywords: Antibacterial activity, quaternary ammonium salts, pyridoxine, cytotoxicity, genotoxicity.
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