ADP-Ribosyltransferases and Poly ADP-Ribosylation

Author(s): Chao Liu, Xiaochun Yu.

Journal Name: Current Protein & Peptide Science

Volume 16 , Issue 6 , 2015

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Abstract:

Protein ADP-ribosylation is an important posttranslational modification that plays versatile roles in multiple biological processes. ADP-ribosylation is catalyzed by a group of enzymes known as ADP-ribosyltransferases (ARTs). Using nicotinamide adenine dinucleotide (NAD+) as the donor, ARTs covalently link single or multiple ADP-ribose moieties from NAD+ to the substrates, forming mono ADP-ribosylation or poly ADP-ribosylation (PARylation). Novel functions of ARTs and ADPribosylation have been revealed over the past few years. Here we summarize the current knowledge on ARTs and PARylation.

Keywords: ADP-ribosylation, ADP-ribosyltransferase, ART, ARTD, PAR, PARylation.

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Article Details

VOLUME: 16
ISSUE: 6
Year: 2015
Page: [491 - 501]
Pages: 11
DOI: 10.2174/1389203716666150504122435
Price: $58

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