Regioselective Synthesis of 2-Chloroquinoline Based Ethyl 4-(3- Hydroxyphenyl)-2,7,7-Trimethyl-5-Oxo-1,4,5,6,7,8-Hexahydroquinoline-3- Carboxylates and their In-Silico Evaluation Against P. falciparum Lactate Dehydrogenase

Author(s): Kancherla Rajesh, Pandian Lavanya, Pethaperumal Iniyavan, Sundaramoorthy Sarveswari, Sudha Ramaiah, Anand Anbarasu, Vijayaparthasarathi Vijayakumar.

Journal Name: Medicinal Chemistry

Volume 11 , Issue 8 , 2015

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Graphical Abstract:


The reaction of various substituted 2, 4-dichloroquinolines with ethyl 4-(3-hydroxyphenyl)- 2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate was carried out in the presence of K2CO3 as a mild and efficient base at controlled temperature leading to novel 2-chloroquinoline based polyhydroquinoline with high regioselectivity. All the synthesized compounds were characterized using IR, NMR, Mass spectral data and then subjected to an in-silico analysis against P. falciparum lactate dehydrogenase.

Keywords: Polyhydroquinoline, 2, 4-Dichloroquinolines, regioselectivity, in-silico analysis, P. falciparum lactate dehydrogenase.

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Article Details

Year: 2015
Page: [789 - 797]
Pages: 9
DOI: 10.2174/1573406411666150430132055
Price: $58

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