The LPS-Pretreated MSCs Supply a Positive Microenvironment for Tumor Cell Proliferation and Clone Formation

Author(s): Pengfei Li , Jin Liu , Junzhong Sun , Haifeng Duan .

Journal Name: Current Protein & Peptide Science

Volume 16 , Issue 4 , 2015

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Abstract:

In this study, the culture supernatant of LPS-treated MSCs was collected and served as a conditioned medium (CM). It was found that the LPS-CM promoted the proliferation of tumor cells (SKBR3, MDA-MB-231, A549, 95D and HepG2). In addition, the colony formation ability was also enhanced by LPS-CM incubation. The inflammatory cytokines, IL-6 and IL-8, were demonstrated to be up-regulated in the LPS-CM, which we supposed to function in the tumor-growth promotion in vitro.

Keywords: Inflammatory cytokine, LPS, MSC, tumor growth.

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Article Details

VOLUME: 16
ISSUE: 4
Year: 2015
Page: [295 - 300]
Pages: 6
DOI: 10.2174/138920371604150429152720
Price: $58

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