Tumor recurrence followed by chemoresistance is a major cause of the poor
survival rates for ovarian cancer. Despite advances in ovarian cancer chemotherapies
and increased knowledge of the characteristics of ovarian cancer, chemoresistance is
still an enormous clinical challenge. Current research suggests that ovarian cancer stem
cells (OCSCs) might be involved in the occurrence of chemoresistance in ovarian
cancer. In this review, we focus on the relationship of ovarian cancer stem cells with
drug-resistant ovarian cancer phenotypes. We also discuss the current knowledge regarding ovarian cancer stem cellbased
therapeutic strategies as attempts to overcome chemoresistance, the largest obstacle for successful treatment. Finally,
we discuss methods for improving the treatment outcomes of ovarian cancer patients with chemoresistance.
Keywords: OCSCs, ovarian cancer, chemoresistance, therapeutic target.
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