Intrahypothalamic Administration of Modafinil Increases Expression of MAP-Kinase in Hypothalamus and Pons in Rats

Author(s): Alwin Poot-Ake, Stephanie Mijangos-Moreno, Danielle Manjarrez-Martin, Ramses Jimenez-Moreno, Pedro R. Aquino-Hernandez, Elda Pacheco-Pantoja, Oscar Arias-Carrion, Andrea Sarro-Ramirez, Gloria Arankowsky-Sandoval, Eric Murillo-Rodriguez.

Journal Name: CNS & Neurological Disorders - Drug Targets

Volume 14 , Issue 4 , 2015

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Abstract:

Modafinil (MOD) it has to be considered as a wake-inducing drug to treat sleep disorders such as excessive sleepiness in narcolepsy, shift-work disorder, and obstructive/sleep apnea syndrome. Current evidence suggests that MOD induces waking involving the dopamine D1 receptor. However, little is known regarding the molecular elements linked in the wake-promoting actions of MOD. Since the D1 receptor activates the mitogen-activated protein kinase (MAP-K) cascade, it raises the interesting possibility that effects of MOD would depend upon the activation of MAP-K. Here we tested the expression of MAP-K in hypothalamus as well as pons after the microinjection of MOD (10 or 20μg/1μL) in rats into anterior hypothalamus, a wake-inducing brain area. Intrahypothalamic injections of MOD promoted MAP-K phosphorylation in hypothalamus and pons. Taken together, these results suggest that the wake-inducing compound MOD promotes the MAP-K phosphorylation.

Keywords: Dopamine, hypothalamus, modafinil, narcolepsy, protein, pons, rat, wakefulness, western blot.

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Article Details

VOLUME: 14
ISSUE: 4
Year: 2015
Page: [463 - 467]
Pages: 5
DOI: 10.2174/1871527314666150429113609
Price: $58

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