Psychopharmacological Issues in Geriatrics

Psychopharmacological Issues in Geriatrics

Indexed in: EBSCO.

Demographic changes due to improved life expectancy and access to medical care has increased the number of people aged 65 years and beyond. This raises an important new challenge for healthcare ...
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Antipsychotics

Pp. 217-240 (24)

Juan Medrano

Abstract

Antipsychotics are those psychiatric drugs primarily used for the treatment of psychosis, mainly schizophrenia. Since their introduction, they have been used in a host of indications, but apart from mood disorders and somatoform disorders or insomnia in some European countries, most non-psychosis uses are off-label. Antipsychotics are associated to serious adverse effects, which call for a careful use, especially in the elderly, a population characterized by pharmacokinetic and pharmacodynamic changes, and frailty. Clozapine, the gold standard antipsychotic, is probably the most difficult to use, but with a judicious use it can be safe and effective in the elderly.

Keywords:

Agranulocytosis, Amisulpride, Aripiprazole, Clozapine, Early Onset Schizophrenia, Extrapyramidal symptoms, First-generation antipsychotics, Haloperidol, Long-acting injections, Metabolic syndrome, Mood stabilizer, Myocardiopathy, Neuroleptic malignant syndrome, Olanzapine, Phenotiazines, Psychotic symptoms, Quetiapine, Risperidone, Schizophrenia with Late Onset, Schizophrenia, Second-generation antipsychotics, Sedation, Somatoform disorder, Tardive dyskinesia, Violence.

Affiliation:

Ezkerraldea - Enkarterri Mental Health Community Services, Bizkaia`s Mental Health Network, Portugalete, Bizkaia/Vizcaya, Spain.