Psychopharmacological Issues in Geriatrics

Psychopharmacological Issues in Geriatrics

Indexed in: EBSCO.

Demographic changes due to improved life expectancy and access to medical care has increased the number of people aged 65 years and beyond. This raises an important new challenge for healthcare ...
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Antidepressants

Pp. 187-216 (30)

Juan Medrano

Abstract

Antidepressants are drugs used for the treatment of depression and many other psychiatric conditions. Albeit belonging to different chemical families and with a number of mechanisms of action, all of them enhance neurotransmitters at the synaptic cleft. They have a range of adverse effects and effectiveness compared with placebo, according to meta-analysis. However, they have shown to be efficacious in the elderly. Second-generation antidepressants are safer and better tolerated, but not devoid of side effects, something not to be forgotten when treating a population in which frailty and polypharmacy are common.

Keywords:

Antidepressants, Arrhythmia, Bipolar disorder, Bupropion, Citalopram, Depression, Duloxetine, Early onset depression, Escitalopram, Hypericum perforatum, Hyponatremia, Late onset depression, Lithium, Mirtazapine, Monoamine oxidease Inhibitors (MAOIs), Obsessive-compulsive disorder, Pharmacokinetic interactions, Rapid cycling, Seizures, Selective serotonin reuptake inhibitors, Serotonin and noradrenalin reuptake inhibitors (SSRIs), Sertraline, Suicide, Trazodone, Tricyclic antidepressants.

Affiliation:

Ezkerraldea - Enkarterri Mental Health Community Services, Bizkaia`s Mental Health Network, Portugalete, Bizkaia/Vizcaya, Spain.