Pathology of the HPV-associated Oropharyngeal Carcinoma

Author(s): Yuki Fukumura.

Journal Name:Current Cancer Therapy Reviews

Volume 11 , Issue 1 , 2015

Graphical Abstract:


Abstract:

Human papilloma virus (HPV)-associated oropharyngeal carcinoma (HPV-OPC) is increasing in many countries. It has distinct microscopic and molecular features as well as clinical aspects. As for microscopic view, two subtypes, non-keratinizing squamous cell carcinoma (NKSCC) and hybrid SCC (HSCC), 3 variants of SCC, undifferentiated carcinoma (UC), basaloid carcinoma (BC), and papillary squamous cell carcinoma (PSCC), and 2 histological structures, abrupt keratinizarion and comedo-necrosis among non-maturing island are related with HPV-OPC. As for molecular aspects, HPV-OPC is more likely to have p53 degradation and Rb (retinoblastoma protein) inactivation with resulting p16 up-regulation compared to HPV-unassociated oropharyngeal carcinoma.

Keywords: Detection method, HPV-associated oropharyngeal carcinoma pathological diagnosis, Human papillomavirus (HPV), molecular diagnosis.

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Article Details

VOLUME: 11
ISSUE: 1
Year: 2015
Page: [3 - 6]
Pages: 4
DOI: 10.2174/1573394711666150428003428