Current Cancer Therapy Reviews

Kurt S. Zaenker
Institute of Immunology and Experimental Oncology University Witten/Herdecke
Stockumerstraße 10, 58448 Witten
Germany

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Rapidly Increasing Trends in Oropharyngeal Carcinoma Assessed by Worldwide Epidemiologic Analysis

Author(s): Enyinnaya Ofo, Junkichi Yokoyama.

Graphical Abstract:


Abstract:

Due to the progressive decline in smoking and drinking, incidences of head and neck cancers have decreased markedly in the USA and European countries. However, incidences of oropharyngeal cancer (OPC) are rising worldwide in both nonsmokers and nondrinkers. Epidemiologic studies suggest a strong association between human papillomavirus (HPV) 16 infection, changing sexual behavior and cancer development.

While HPV-associated oropharyngeal carcinoma is characterized by locally advanced disease and poorly differentiated histology, HPV-associated OPC is identified with effective prognosis by reason of its positive response to chemotherapy and radiation. Nevertheless, clinicians need to be aware of the risk of OPC in young people in order to avoid unnecessary delays in diagnosis and treatment.

Interviews with attention to obtaining information including the patient’s history of oral sex can aid in establishing a precise diagnoses in young patients with enlarged neck nodes and/or tonsillar masses.

Keywords: Epidemiology, HPV associated oropharyngeal carcinoma, human papillomavirus (HPV), oropharyngeal carcinoma, prevention, vaccination.

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Article Details

VOLUME: 11
ISSUE: 1
Year: 2015
Page: [15 - 20]
Pages: 6
DOI: 10.2174/1573394711666150428003039