Anxiolytic-Like Effects of 7H-Benzo[e]perimidin-7-One Derivatives through Elevated Plus-Maze Test in Mice

Author(s): Jorge Nunez, Jose A. Fontenla, Seyed Mohammad Nabavi, Eugenio Uriarte, Alejandra Herrera, Eduardo Sobarzo-Sanchez.

Journal Name: Current Topics in Medicinal Chemistry

Volume 15 , Issue 17 , 2015

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Abstract:

Anxiety is one of the behavior disorders that has been studied more together with depression in the world, and that has enormous interference in the mental health of the affected patients. The states of panic and phobia are a part of the psychological characteristics that some drugs have tried to control though with varied side effects that are proven to be difficult to control. The use of perimidinone derivatives against the effects of anxiety has generated that A5 is the most active and selective anxiolytic compound, differing with regard to diazepam (DZP) used as control reference in elevated plus-maze (EPM) test. This test allows to conclude that it is feasible to differentiate the use selective as anxiolytic or antidepressant of certain perimidinones, because A4 had been characterized by our research group as an important antidepressant respect to A5 studied in previous reports.

Keywords: 7H-benzo[e]perimidin-7-one, Anxiety, Depression, Oxoisoaporphines, Perimidinones, Plus-maze test.

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Article Details

VOLUME: 15
ISSUE: 17
Year: 2015
Page: [1750 - 1754]
Pages: 5
DOI: 10.2174/1568026615666150427125535
Price: $58

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