Central Nervous System Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Central Nervous System Agents)

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Biological Activities of QIAPI 1 as a Melanin Precursor and Its Therapeutic Effects in Wistar Rats Exposed to Arsenic Poisoning

Author(s): Arturo Solis-Herrera, Ghulam M. Ashraf, Maria del C.A. Esparza, Ruth I.S. Arias, Sergei O. Bachurin, George E. Barreto, Gjumrakch Aliev.

Graphical Abstract:


Abstract:

The chemical process initiated by QIAPI 1 has been deemed to be the most important biological reaction associated with human photosynthesis, and possibly neuroprotective effects under various inflammatory events. However, the detailed biological activities of QIAPI 1 as a melanin precursor are still unknown. In the present work, cytotoxicity test was done by MTT assay to determine cell viability of various cell lines (WI-38, A549, HS 683) like proliferation tests and its effect on cytokine production. Arsenic poisoning is an often-unrecognized cause of renal insufficiency. No prophylactic and/or therapeutic compounds have shown promising results against kidney diseases. The pathogenesis of Arsenicinduced nephropathy is not clear. Arsenic, as itself, does not degrade over time in the environment, and its accumulation may induce toxic effects. In this study, we also report the histological findings of the kidney in 3 groups of Wistar rats, a control group, a group exposed to arsenic in the water; and a group exposed to arsenic and treated with QIAPI 1 simultaneously. The findings of the current evidence indicates a potential therapeutic ability of QIAPI 1.

Keywords: Arsenic, cytotoxicity, human photosynthesis, melanin, QIAPI 1.

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Article Details

VOLUME: 15
ISSUE: 2
Year: 2015
Page: [99 - 108]
Pages: 10
DOI: 10.2174/1871524915666150424113831
Price: $58