Biological Activities of QIAPI 1 as a Melanin Precursor and Its Therapeutic Effects in Wistar Rats Exposed to Arsenic Poisoning
Ghulam M. Ashraf,
Maria del C.A. Esparza,
Ruth I.S. Arias,
Sergei O. Bachurin,
George E. Barreto,
The chemical process initiated by QIAPI 1 has been deemed to be the most important biological reaction associated
with human photosynthesis, and possibly neuroprotective effects under various inflammatory events. However, the
detailed biological activities of QIAPI 1 as a melanin precursor are still unknown. In the present work, cytotoxicity test
was done by MTT assay to determine cell viability of various cell lines (WI-38, A549, HS 683) like proliferation tests and
its effect on cytokine production. Arsenic poisoning is an often-unrecognized cause of renal insufficiency. No prophylactic
and/or therapeutic compounds have shown promising results against kidney diseases. The pathogenesis of Arsenicinduced
nephropathy is not clear. Arsenic, as itself, does not degrade over time in the environment, and its accumulation
may induce toxic effects. In this study, we also report the histological findings of the kidney in 3 groups of Wistar rats, a
control group, a group exposed to arsenic in the water; and a group exposed to arsenic and treated with QIAPI 1 simultaneously.
The findings of the current evidence indicates a potential therapeutic ability of QIAPI 1.
Keywords: Arsenic, cytotoxicity, human photosynthesis, melanin, QIAPI 1.
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