An efficient and selective synthesis of substituted chromene derivatives via threecomponent
reaction of 4-hydroxycoumarin or 1,3-dicarbonyl compounds, activated acetylenic
compounds and N-nucleophiles is described. The reaction was conducted under solvent-free
conditions at 70°C using potassium fluoride impregnated on natural zeolite as a cheap and available
solid base. The procedure has several advantages involving selectivity, excellent yields and a
convenient work-up method.
Keywords: 4-hydroxycoumarin, acetylenic compounds, N-nucleophiles, solvent-free.
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