Along with the exuberant development of nanotechnology, a large number of
nanoformulations or non materials are successfully applied in the clinics, biomedicine, cosmetics and
industry. Despite some unique advantages of nanoformulations, there exist potentially worrying toxic
effects, particularly those related to metal and metal-containing nanoparticles (NPs). Although various
researches have been conducted to assess the metallic and metal-containing nanoparticles toxic effects, only little is
known about the toxicity expressive types and evaluation, reasons and mechanisms, influencing factors and research
methods of metal and metal-containing nanotoxicity. Therefore, it is of importance to acquire a better understanding of
metal and metal-containing nanoparticles toxicity for medical application. This review presents a summary on the metal
and metal-containing nanoparticles toxicity research progress consulting relevant literature.
Keywords: Influencing factors, metal and metal-containing nanoparticles, reason and mechanism, research methods, toxicity
expressive types, toxicity research progress.
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