There is increasing evidence that nutritional and hormonal signals during development can
influence longevity. It was reported that mice subjected to mild calorie restriction only during the
preweaning period live longer than control animals. In long-lived hypopituitary dwarf mice, longevity
can be reduced by growth hormone replacement therapy during pre- and peri-pubertal period. These
findings suggest that trajectory of aging is importantly influenced by the availability of nutrients and
the levels of anabolic hormones during development.
Keywords: Aging, longevity, calorie restriction, hypopituitary dwarf mice.
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