Towards an Evidence-based Model of Aging
Harold L. Katcher.
The modern synthesis or evolutionary theory of aging assumes that aging results from the accumulation of errors
or damages at the cellular level through the inadequacies of an organism's repair and maintenance machinery. The
demonstration of cellular and organic rejuvenation requires the hypothesis that aging is the result of irreparable damage to
be rejected. I will propose basic principles of mammalian aging based only on experimental data, without imposing the
constraints of evolutionary theory. Consideration of the results of experiment suggests that fundamental assumptions
about cell and organ aging being autonomous process, and about the centrality of cellular aging in organismic aging are
wrong. The derived principles indicate that exogenous control of age-phenotype at cellular and higher levels of biological
organization is possible.
Keywords: Aging, programmed aging, 'wear and tear' aging, disposable soma, hallmarks of aging, rejuvenation, cellular aging,
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