Abstract
Cancer kinome is now well organized as an important target for a new class of cancer drugs. There are more than 500 members in the kinase family in which some of them are clinically analysed, while the rest are under investigation for potential therapeutic applications. Phosphorylation, major function of kinases is one of the most significant signal transduction mechanism in which intercellular signals regulate intracellular processes like ion transport, hormone responses and cellular proliferation. Any deregulation of kinase function may lead to tumor progression and other disorders such as immunological, neurological , metabolic including also infectious diseases. This led to the necessity in the development of kinase inhibitors as therapeutic agent. Herein we discuss about different types of kinases and their inhibitors in various types of cancers. This review portrays a broad overview of the origin of kinases, discovery, the characterization and mode of action of kinase inhibitors in cancer therapy.
Keywords: Kinases, kinase inhibitors, cancer, small molecules, kinase family, anticancer therapy.
Current Drug Targets
Title:Cancer Kinases and its Novel Inhibitors: Past, Present and Future Challenges
Volume: 16 Issue: 11
Author(s): Prathesha Pillai, R.S. Surenya, Shantikumar V. Nair and Vinoth-Kumar Lakshmanan
Affiliation:
Keywords: Kinases, kinase inhibitors, cancer, small molecules, kinase family, anticancer therapy.
Abstract: Cancer kinome is now well organized as an important target for a new class of cancer drugs. There are more than 500 members in the kinase family in which some of them are clinically analysed, while the rest are under investigation for potential therapeutic applications. Phosphorylation, major function of kinases is one of the most significant signal transduction mechanism in which intercellular signals regulate intracellular processes like ion transport, hormone responses and cellular proliferation. Any deregulation of kinase function may lead to tumor progression and other disorders such as immunological, neurological , metabolic including also infectious diseases. This led to the necessity in the development of kinase inhibitors as therapeutic agent. Herein we discuss about different types of kinases and their inhibitors in various types of cancers. This review portrays a broad overview of the origin of kinases, discovery, the characterization and mode of action of kinase inhibitors in cancer therapy.
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Pillai Prathesha, Surenya R.S., Nair V. Shantikumar and Lakshmanan Vinoth-Kumar, Cancer Kinases and its Novel Inhibitors: Past, Present and Future Challenges, Current Drug Targets 2015; 16 (11) . https://dx.doi.org/10.2174/1389450116666150416120108
DOI https://dx.doi.org/10.2174/1389450116666150416120108 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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