In recent years, beneficial effects of various ligands of three peroxisome-proliferatoractivated
receptor (PPAR) isoforms (α, β, γ) have been reported in neurodegenerative diseases through
delaying the onset and progression of diseases, reducing lesion size and improving functional recovery.
Neural stem cells (NSCs) are assumed as a promising strategy for the treatment of human neurodegenerative
diseases. PPARs are supposed to be one group of the key regulators of fate decisions in25882852
neural stem cells during development and adulthood, through their impact on the target genes involving
cell proliferation, death and differentiation. The neuroprotective role of PPARs is suggested to be closely associated
with the inflammation control and regenerative function of NSCs. Nevertheless, the molecular mechanisms remain to be
elucidated. Here, we review the current knowledge about the beneficial role of PPARs in NSC development and neurogenesis
and attempt to discuss the underlying mechanisms.
Keywords: Human neurodegenerative diseases, inflammation, neural stem cells, neurogenesis, neuroprotective role, peroxisome-
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