Manufacturing Solid Dosage Forms from Bulk Liquids Using the Fluid-bed Drying Technology

Author(s): Jianping Qi , Y i Lu , Wei Wu .

Journal Name: Current Pharmaceutical Design

Volume 21 , Issue 19 , 2015

Abstract:

Solid dosage forms are better than liquid dosage forms in many ways, such as improved physical and chemical stability, ease of storage and transportation, improved handling properties, and patient compliance. Therefore, it is required to transform dosage forms of liquid origins into solid dosage forms. The functional approaches are to absorb the liquids by solid excipients or through drying. The conventional drying technologies for this purpose include drying by heating, vacuum-, freeze- and spray-drying, etc. Among these drying technologies, fluidbed drying emerges as a new technology that possesses unique advantages. Fluid-bed drying or coating is highly efficient in solvent removal, can be performed at relatively low temperatures, and is a one-step process to manufacture formulations in pellet forms. In this article, the status of the art of manufacturing solid dosage forms from bulk liquids by fluid-bed drying technology was reviewed emphasizing on its application in solid dispersion, inclusion complexes, self-microemulsifying systems, and various nanoscale drug delivery systems.

Keywords: Fluid-bed, drying, solidification, solid dispersion, inclusion complex, nanoparticles.

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Article Details

VOLUME: 21
ISSUE: 19
Year: 2015
Page: [2668 - 2676]
Pages: 9
DOI: 10.2174/1381612821666150416100639
Price: $58

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