Title:Conducting and Biopolymer Based Electrospun Nanofiber Membranes for Wound Healing Applications
VOLUME: 12 ISSUE: 2
Author(s):Mohammad R. Karim, Abdurahman Al-Ahmari, M.A. Dar, M.O. Aijaz, M.L. Mollah, P.M. Ajayan, J.H. Yeum and Kil-Soo Kim
Affiliation:Center of Excellence for Research in Engineering Materials, Advanced Manufacturing Institute, King Saud University, Riyadh 11421, Kingdom of Saudi Arabia.
Keywords:Biopolymers, conducting polymer, electrospinning, nanofibers, wound healing.
Abstract:Background: Electrospinning is a modest and real tactic to harvest nanofiber membranes from micrometers to
nanometers scale diameters, are useful in modern nanotechnology like biomedical, filtration, defense, catalysis, sensor and
energy applications. Wound healing practice is deliberated a constant morphological modification of cells with the alteration
of cell exodus, adherence, etc. In this characteristic, the advance of polymeric nanofiber scaffolds with together biodegradable
and electrically conducting properties would be pronounced benefits in the biomedical field. Here it has been
established the conducting polymer and biopolymer based electrospun nanofiber membranes exploited on wound healing
and wound-size decline in rats successfully.
Methods: Ultrafine conducting polyaniline with o-aminobenzenesulfonic acid copolymer (PAni-co-PABSA) and poly
(vinyl alcohol) (PVA)/chitosan oligossacaride (COS) biopolymers based electrospun nanofiber membranes have been exploited
for wound healing applications. The nanofiber membranes were assembled by spawning double full-thickness skin
wounds on the dorsum of SD rats.
Results: The current study is commenced to appraise the potentials for use of PAni-co-PABSA/PVA/COS electrospun
nanofibers in wound healing in rats. The nanofiber membranes cured wounds show considerable lesser provocative responses
throughout the experimental period. Area of nanofiber membranes and commercial (Fucidin®) ointment treated
wounds are significantly decreased equate to control cured wounds. After 15 days treatment, the histological appearance
by nanofiber membranes reveal almost complete healing and intensification in collagen and granulation as compare to
control one.
Conclusion: The nanofiber membranes cured wounds have ample reduced inflammatory responses throughout the experimental
period. Histological appearance after two weeks of management with PAni-co-PABSA/PVA/COS nanofiber
reveals almost complete healing and an increase in collagen and granulation as compare to control.
