A Review on Recent Robotic and Analytic Technologies in High Throughput Screening and Synthesis for Drug Discovery

Author(s): Min Zhu.

Journal Name: Letters in Drug Design & Discovery

Volume 12 , Issue 9 , 2015

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Abstract:

High-throughput screening (HTS) has achieved widespread popularity over the last two to three decades in drug discovery. Characterized by its simplicity, rapidness, low cost, and high efficiency, HTS can minimize the time span of drug discovery noticeably. Robotic technologies and analytic technologies are two central components of HTS, and significant progress of the technologies has been reported recently. In addition, microfluidics has emerged as a promising technology in HTS with eligible potential. Lastly, although automated synthesis is not generally seen as a part of HTS, there is a great desire for the development of high throughput synthesis to generate compound libraries and its integration into HTS. Herein the most recent advancements in the four above mentioned fields are reviewed.

Keywords: High throughput screening, robotics, microfluidics, high throughput synthesis.

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Article Details

VOLUME: 12
ISSUE: 9
Year: 2015
Page: [778 - 784]
Pages: 7
DOI: 10.2174/1570180812666150414215346
Price: $58

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