Zwitterionic Imidazolium Salt: An Efficient Organocatalyst for the One-Pot Synthesis of 5,6-Unsubstituted 1,4-Dihydropyridine Scaffolds

Author(s): Avik Kumar Bagdi, Dhiman Kundu, Adinath Majee, Alakananda Hajra.

Journal Name: Current Organocatalysis

Volume 3 , Issue 2 , 2016

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An efficient, simple and environmentally benign methodology has been developed for the synthesis of 5,6-unsubstituted 1,4-dihydropyridine derivatives by a three-component condensation of β-keto esters, amines and α,β-unsaturated aldehydes under solvent-free conditions catalyzed by an aprotic imidazole-based zwitterionic salt. The key advantages of this protocol are metal-free reaction conditions, short reaction time, high yields, reusability of the catalyst, and easy work-up. A variety of dihydropyridine derivatives have been synthesized with high yields at room temperature and only water is formed as a green by-product.

Keywords: Dihydropyridines, imidazolium zwitterion, multicomponent, organocatalysis, reusability, solvent-free.

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Article Details

Year: 2016
Page: [169 - 175]
Pages: 7
DOI: 10.2174/2213337202666150414201734
Price: $58

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