Although vaccines and antibiotics could kill or inhibit microbes, many infectious diseases remain
difficult to treat because of acquired resistance and adverse side effects. Nano-carriers-based technology
has made significant progress for a long time and is introducing a new paradigm in drug delivery.
However, it still has some challenges like lack of specificity toward targeting the infectious site. Nanocarriers
utilized targeting ligands on their surface called ‘active target’ provide the promising way to
solve the problems like accelerating drug delivery to infectious areas and preventing toxicity or sideeffects.
In this mini review, we demonstrate the recent studies using the active targeted strategy to kill or inhibit microbes.
The four common nano-carriers (e.g. liposomes, nanoparticles, dendrimers and carbon nanotubes) delivering encapsulated
drugs are introduced.
Keywords: Active target, Ligands, Microbe, Nano-carrier.
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