Aptamers- short nucleic acid or peptide ligands- attracted considerable attention across
various disciplines as target specific therapeutic, delivery vehicle and diagnostic tools. The applicability
of aptamers - often termed as ‘chemical antibodies’ – continues to grow and possess certain edge
over the antibody counterpart. In this special issue, we have invited seven contributors to highlight the
chemical biology, therapeutic, biosensor and imaging applications of aptamers. Furthermore, the issue
end with an outlook of aptamer technology after 25 years of history.