Aptamers represent the novel class of oligonucleotides holding multiple applications in the
area of biomedicine. The advancements introduced with the Systematic Evolution of Ligands by EXponential
enrichment (SELEX) approach further eased the scope of producing modified aptamers
within a short span yet retaining the properties of stability and applicability. In the recent times, aptamers
were identified to have the potential for penetrating into the deep human crevices and thus can be utilized in addressing
the issues of complex neurological disorders. Considering the specificity and stability enhancement by chemical
modifications, aptamer-based nanotechnologies may have great potential for future therapeutics and diagnostics (theranostics).
The research community has already witnessed success with the approval of macugen (an anti-vascular endothelial
growth factor aptamer) for treating degenerating eye disease, and hopefully those that are in the clinical trials will soon be
translated for human application. Herein, we have summarized the aptamer chemistry, aptamer-nanoconjugates and their
applications against neurological diseases.
Keywords: Aptamers, Blood brain barrier, Nano-aptamer conjugation, Neurological diseases, Pharmacokinetics, SELEX.
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