Peptide Aptamers: Development and Applications

Author(s): Sergey Reverdatto, David S. Burz, Alexander Shekhtman.

Journal Name: Current Topics in Medicinal Chemistry

Volume 15 , Issue 12 , 2015

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Abstract:

Peptide aptamers are small combinatorial proteins that are selected to bind to specific sites on their target molecules. Peptide aptamers consist of short, 5-20 amino acid residues long sequences, typically embedded as a loop within a stable protein scaffold. Various peptide aptamer scaffolds and in vitro and in vivo selection techniques are reviewed with emphasis on specific biomedical, bioimaging, and bioanalytical applications.

Keywords: Affibodies, Affilins, Anticalins, Armadillo repeat, Atrimers, Avimers, Cell display, Combinatorial libraries, Darpins, Directed evolution, DNA display, Fynomers, Knottins, Kunitz domain, Monobodies, mRNA display, OBodies, Phage display, Peptide aptamers, Protein scaffold, Ribosome display, Thioredoxin, Yeast two hybrid.

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Article Details

VOLUME: 15
ISSUE: 12
Year: 2015
Page: [1082 - 1101]
Pages: 20
DOI: 10.2174/1568026615666150413153143
Price: $58

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