Iron deficiency anemia (IDA) is the commonest nutritional problem responsible for 50% cases of
anemia worldwide. An extensively searched literature revealed that Iron deficiency anemia is found to be the
most common nutritional disorder among Pakistani population. Early Identification of IDA and administering
the appropriate therapy are of paramount importance in its management.
The study is aimed to determine the serum hepcidin level in IDA patients and its correlation with serum ferritin,
iron and hemoglobin. Methods: This was a pilot study including 25 patients of Iron deficiency anemia
(IDA). Patients were enrolled from Life Line medical and Diagnostic Centre from May 2014 to August 2014.
All patients of age > 13 years with given written consent were enrolled. Complete blood count and Iron profile/
studies were conducted.
Out of twenty five patients with iron deficiency anemia, 14 patients (56%) were female while 11(44%) were
male. The mean hemoglobin concentration was 8.544 ± 1.54 g/dL, serum ferritin was 9.09±1.35 ng/dL and
serum iron was 27.2±6.78μg/dL. The mean serum hepcidin level of patients was 13.2± 1.03ng/ml. Three iron
deficiency parameters were correlated with serum hepcidin level. Serum ferritin had technically weak positive
correlation with serum hepcidin (r = 0. 021, determination coefficient R= 0.048). Serum iron also had weak
positive correlation with serum hepcidin (r = 0. 25, determination coefficient R= 0.066). Serum iron also had
weak positive correlation with serum hepcidin (r = 0. 25, determination coefficient R= 0.066). Hemoglobin
had a negative correlation with serum hepcidin (r = -0.06, determination coefficient R= 0.004).
This pilot study showed weak positive correlation between serum hepcidin with serum iron and serum ferritin
level in patients with iron deficiency anemia. Study further showed negative correlation between hemoglobin
levels with serum hepcidin. Further large scale studies are required to confirm this correlation along with determination
of serum hepcidin as a diagnostic marker for iron deficiency anemia.