Bridging the Gap: The Potential Role of Corticosteroid Binding Globulin in Cardiac Steroid Facilitation

Author(s): Hans Hendrik Schafer, Thomas Dieterle, Aaron Trachsler, Mikael Gencay, Edelgard Anna.

Journal Name: Current Drug Targets

Volume 16 , Issue 11 , 2015

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Abstract:

Corticosteroid (glucocorticoids [GCs] and mineralcorticoids [MCs]) interact directly with cells of the cardiovascular system. Their signaling affects genomic and non-genomic receptors and comprises a multitude of alternative and interfering levels of interaction, which influence the physiological response. This review describes genomic and non-genomic pathways of steroid facilitation and portrays the current body of knowledge regarding corticosteroid-binding globulin (CBG). The latter is a carrier protein facilitating corticosteroid availability in the circulation and has recently been discovered intrinsically in cardiomyocytes. Thought experiments highlight potential areas of clinical research and hypotheses are presented for steroid- carrier interaction. Furthermore, this review comprises a conclusive overview of disease conditions and substances that influence CBG levels and summarizes the potential of CBG as a potential future biomarker.

Keywords: Corticosteroid-steroid binding, drug, glucocorticoids, heart, humans, mineralocorticoids.

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Article Details

VOLUME: 16
ISSUE: 11
Year: 2015
Page: [1254 - 1269]
Pages: 16
DOI: 10.2174/1389450116666150408103806
Price: $58

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