Oxime K203 seems to be the most promising oxime in case of reactivation of tabuninhibited
acetylcholinesterase (AChE). Although it was originally developed for treatment of tabun intoxications, it is able
to reactivate cholinesterases inhibited by other nerve agents. This study is aimed at the evaluation of its potency in vitro
against other nerve agents. For this purpose, sarin, tabun, cyclosarin, soman, VX, Russian VX and DFP were selected as
members of the nerve agent family to check its universality. At high concentrations (10-3 M), oxime K203 reached promising
reactivation activity. At low concentrations, relevant for human use (10-5 M), promising reactivation potency was
obtained only with tabun. In conclusion, oxime K203 reactivates other nerve agents-inhibited cholinesterases, however its
broad-spectrum reactivation is limited at high, for human not attainable, concentrations only.