The aim of the study was to investigate the safety and anti-inflammatory effects
of polysaccharide fraction (F1) of Curcuma longa extract (NR-INF-02) in classical rodent
models of inflammation. F1 was evaluated for its acute oral toxicity and found to be safe upto
5000 mg/kg body weight in rats. The anti-inflammatory activity of F1 was evaluated in
acute (carrageenan - induced paw edema; xylene - induced ear edema) and chronic (cotton
pellet - induced granuloma) models of inflammation. The results of the study demonstrated
that F1 significantly (p ≤ 0.05) inhibited carrageenan-induced paw edema at 1 h and 3 h at
doses of 11.25, 22.5 and 45 mg/kg body weight in rats. Also, F1 at doses of 15.75, 31.5 and 63 mg/kg significantly
inhibited the xylene induced ear edema in mice. In a chronic model, F1 at 11.25, 22.5 and 45 mg/kg doses
produced significant reduction of wet and dry weights of cotton pellets in rats. Overall results indicated that
F1 of NR-INF-02 significantly attenuated acute and chronic inflammation in rodent models. This study emphasizes
on the importance of Curcuma longa polysaccharide’s role in acute and chronic inflammation.
Keywords: Anti-inflammatory, Curcuma longa, NR-INF-02, Polysaccharide fraction.
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