Current Cancer Drug Targets

Ruiwen Zhang 
Texas Tech University Health Sciences Center
1300 Coulter Drive
Amarillo, TX 79106
USA

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Nanoradiopharmaceuticals for Bone Cancer Metastasis Imaging

Author(s): Bianca Feliciano Coelho, Marta de Souza Albernaz, Alexandre Iscaife, Katia Ramos Moreira Leite, Mara de Souza Junqueira, Emerson Soares Bernardes, Emerson Oliveira da Silva, Ralph Santos-Oliveira.

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Abstract:

Drug delivery systems are under intense investigation all around the world, especially in oncology research. Indeed, in some cases, like bone metastasis, nanodrugs may represent the last and best choice for both treatment and imaging of early cancer foci. Nuclear medicine has been using MDP labelled with 99mTc as radiopharmaceuticals for many years; however, their use as nanoradiopharmaceuticals is very innovative and creates a new way to establish radiopharmacy in this new scenario offered by nanotechnology. In this study we developed and tested nano-MDP-labelled with 99mTc in rats induced with bone cancer metastasis and the results showed that it may work in patients. However, some further experiments are required in order to initiate protocols in humans.

Keywords: Bone, nanotechnology, oncology, radiopharmaceuticals.

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Article Details

VOLUME: 15
ISSUE: 5
Year: 2015
Page: [445 - 449]
Pages: 5
DOI: 10.2174/1568009615666150407125020
Price: $58