Lipophilic Statins as Anticancer Agents: Molecular Targeted Actions and Proposal in Advanced Gynaecological Malignancies

Author(s): Salvatore Gizzo, Michela Quaranta, Giovanni Battista Nardelli, Marco Noventa.

Journal Name: Current Drug Targets

Volume 16 , Issue 10 , 2015

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Abstract:

Despite adequate surgery, women affected by advanced-stage gynaecological cancers (ovarian/ endometrial malignancies) carry an extremely poor prognosis; an improved oncological prognosis could largely depend upon the enhancement of adjuvant treatment. Recent data showed that, among women affected by endometrial/ovarian malignancies, a reduced cancer-related mortality was noted in statin-users compared to non-users, suggesting the need for clinical trials to define the anticancerproperties of statins. In vitro/in vivo evidences suggest a potential chemo-preventive effect through induction of cancer-cell apoptosis and inhibition of cancer-cell growth, proliferation, invasion, and metastasis. The potential oncological impact of this discovery compels us to investigate all possible molecular targets for anticancer activities of statins in order to identify a rationale in proposing their administration in association with standard chemotherapy/radiotherapy protocols after adequate surgical-treatment for advanced-stages gynaecological malignancies.

Keywords: Adjuvant treatments, advanced stages of cancer, anticancer agents, gynaecological malignancies, pleiotropic action of drugs, statin use.

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Article Details

VOLUME: 16
ISSUE: 10
Year: 2015
Page: [1142 - 1159]
Pages: 18
DOI: 10.2174/1389450116666150330113239
Price: $65

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