Antibacterial Properties of Tetraalkylammonium and Imidazolium Tetraalkoxycalixarene Derivatives
Iryna O. Melezhyk,
Roman V. Rodik,
Nataliia V. Iavorska,
Andrey S. Klymchenko,
Victoriia V. Shepelevych,
Larisa M. Skivka,
Vitaly I. Kalchenko.
The antibacterial and antibiofilm activities of several amphiphillic tetracationic calixarenes
with different functional groups were evaluated. Our results demonstrate the clear dependence of antibacterial
activity from the alkyl chain length on the lower rim of calixarene. Tetrapropoxycalixarenes
have 10-50 times higher antibacterial activity than tetraoctyl calixarenes with same cationic residues
on the upper rim. At the same time, one of the tetrapropoxycalixarenes shows high inhibitory activity
against Staphylococcus aureus biofilms. Therefore, the alkyl chain length is an important characteristic that can be used
for further antibacterial agent design.
Keywords: Antibacterial, biofilm, calixarene, QAS, structure-activity relationship.
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