Synthesis and Anticancer Activity of 1, 3, 5-Triaryl-1H-Pyrazole

Title:Synthesis and Anticancer Activity of 1, 3, 5-Triaryl-1H-Pyrazole

Volume: 12 Issue: 9

Author(s): Sajad Ghadbeigi, Seyed Nasser Ostad, Abbas Shafiee and Mohsen Amini

Affiliation:

Keywords: Tri-arylpyrazole, cytotoxicity, synthesis, HT-29, MCF-7, AGS.

Abstract: Previous studies demonstrated that some pyrazole derivatives could be considered as potential anticancer agents. A series of 1,3,5-triaryl-1H-pyrazole derivatives were prepared by the reaction of phenylhydrazin and different chalcones. The previous classic synthesis method was developed for a simpler procedure. The cytotoxicity of these compounds was determined against three cancer cell lines (HT-29), (MCF-7), (AGS) as well as fibroblastic cell line (NIH-3T3) using MTT assay. These biological studies proved that 5f and 5l were the most potent compounds in this series. Furthermore, 5f showed a partial selectivity in cytotoxicity effect between the cancerous and normal cell lines.

Cite this article as:

Ghadbeigi Sajad, Nasser Ostad Seyed, Shafiee Abbas and Amini Mohsen, Synthesis and Anticancer Activity of 1, 3, 5-Triaryl-1H-Pyrazole, Letters in Drug Design & Discovery 2015; 12 (9) . https://dx.doi.org/10.2174/1570180812666150326004723