Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis and Anticancer Activity of 1, 3, 5-Triaryl-1H-Pyrazole

Author(s): Sajad Ghadbeigi, Seyed Nasser Ostad, Abbas Shafiee, Mohsen Amini.

Graphical Abstract:


Abstract:

Previous studies demonstrated that some pyrazole derivatives could be considered as potential anticancer agents. A series of 1,3,5-triaryl-1H-pyrazole derivatives were prepared by the reaction of phenylhydrazin and different chalcones. The previous classic synthesis method was developed for a simpler procedure. The cytotoxicity of these compounds was determined against three cancer cell lines (HT-29), (MCF-7), (AGS) as well as fibroblastic cell line (NIH-3T3) using MTT assay. These biological studies proved that 5f and 5l were the most potent compounds in this series. Furthermore, 5f showed a partial selectivity in cytotoxicity effect between the cancerous and normal cell lines.

Keywords: Tri-arylpyrazole, cytotoxicity, synthesis, HT-29, MCF-7, AGS.

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Article Details

VOLUME: 12
ISSUE: 9
Year: 2015
Page: [754 - 759]
Pages: 6
DOI: 10.2174/1570180812666150326004723
Price: $58