Mutations in mitochondrial genes, oxidative insults, imbalance in redox mechanisms and
dysregulated mitophagy are some of the leading causes for mitochondrial dysfunction and subsequent
neurodegeneration in Parkinson’s disease. Targeting mitochondrial dysfunction and prolonging
neuronal survival could potentially prove to be useful neuroprotective strategies. In some recent
investigations, peroxisome proliferator activated receptor gamma coactivator 1 alpha mediated
mitochondrial biogenesis and its ability to restore reactive oxygen species-detoxifying enzymes have
been observed in preclinical studies. In this review, we discuss about physiological importance of peroxisome proliferator
activated receptor gamma coactivator 1 alpha along with a list of its activators that could prove useful as possible
neuroprotectants in Parkinson’s disease.
Keywords: Mitochondrial biogenesis, Mitochondrial transcription factor A, Neurodegeneration, Parkinson’s disease, Reactive
oxygen species, Sirtuin 1.
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