This systematic review evaluates the prevalence of long-term complications of serogroup B meningococcal
disease (MD) in light of the recent licensure of a vaccine against meningococcal B disease. Twelve appropriate studies
were identified by searching available databases from 1946 to July 2014. The average prevalence of hearing impairment
was 4.2% among serogroup B MD survivors; 2.3% suffered amputation and 2.3% developed seizures. When compared
with complications due to non-meningococcal B bacterial meningitis, physical impairment and seizures were more common
in survivors of meningococcal B disease but hearing impairment had similar prevalence. Few studies quantified less
frequent complications such as visual impairment and cognitive dysfunction. Better comprehensive reporting of the complications
and costs of serogroup B MD in survivors and their families is needed to inform vaccination policy.
Keywords: Complications, meningococcal disease, serogroup B.
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