The Role of Transforming Growth Factor β1 in the Regulation of Blood Pressure

Author(s): Kota Matsuki , Catherine K. Hathaway , Marlon G. Lawrence , Oliver Smithies , Masao Kakoki .

Journal Name: Current Hypertension Reviews

Volume 10 , Issue 4 , 2014

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Abstract:

Although human association studies suggest a link between polymorphisms in the gene encoding transforming growth factor (TGF) β1 and differing blood pressure levels, a causative mechanism for this correlation remains elusive. Recently we have generated a series of mice with graded expression of TGFβ1, ranging from approximately 10% to 300% compared to normal. We have found that blood pressure and plasma volume are negatively regulated by TGFβ1. Of note, the 10% hypomorph exhibits primary aldosteronism and markedly impaired urinary excretion of water and electrolytes. We here review previous literature highlighting the importance of TGFβ signaling as a natriuretic system, which we postulate is a causative mechanism explaining how polymorphisms in TGFβ1 could influence blood pressure levels.

Keywords: Corticosteroid, collecting duct, epithelial sodium channel, endothelin, nitric oxide.

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Article Details

VOLUME: 10
ISSUE: 4
Year: 2014
Page: [223 - 238]
Pages: 16
DOI: 10.2174/157340211004150319123313
Price: $58

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